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In a previous study, transcriptomic profiling of brain regions involved in the brains reward circuitry (prefrontal cortex, dorsal striatum, nucleus accumbens, basolateral amygdala, ventral hippocampus, and ventral tegmental area) revealed considerable changes in transcript expression during the cocaine self-administration, withdrawal, and relapse phases, with the greatest changes detected in the re-exposure phase 40
Cardiomyopathy (dilated or hypertrophic) is more frequent in patients older than 1 year of age associated sometimes with hypotonia
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Ankar A, et al
