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Cytoplasmic and Mitochondrial Tetrahydrofolate Interconversions A member of the folate metabolism family of enzymes, encoded by the MTHFD1 gene, can generate NADPH in the course of the conversion of N 5 , N 10 -methylene-tetrahydrofolate (5,10-methylene-THF) to 5,10-methenyl-THF

Interestingly, recent studies revealed that ferroptosis has been implicated in sodium iodate-induced ARPE-19 necrobiosis, indicating that ferroptosis participates in retinal degeneration, which provides evidence on the association of ferroptosis with RP (47, 82)

In our study, we identified GSTM5 mRNA as a potential target mRNA of IGF2BP2

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