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Increased tear osmolarity in dry eye disease has been found to stimulate production of inflammatory cytokines and matrix metalloproteinases by ocular surface epithelial cells [155]

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hence, the common name of the enzyme catalyzing this reaction: thiolase

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347 A separate study found that adults aged 20-40 years given 20 mg PQQ daily for 12 weeks had a significant improvement in processing speed and executive speed after eight weeks compared with placebo

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