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Below pH 5.0, copper ions detach, leading to a total loss of efficacy

The clinical titration starts at 0.25 mg weekly and increases every four weeks up to a maintenance dose of 2.4 mg weekly, though some research protocols extend up to 4.5 mg

Glutathione: biosynthesis, metabolism and relationship to stress resistance explored in transformed plants

Furthermore, we systematically summarize key molecular mechanisms underlying cuproptosis and evaluate the potential of cuproptosis-based cancer therapies, including their effects on the tumor immune microenvironment