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Al-Hujaily EM, Mohamed AG, Al-Sharif I, et al
ROS generated by mitochondria can enter the ER and trigger the unfolded protein response (UPR), which can activate three types of ER transmembrane protein receptors: Protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor-6 (ATF-6) and inosital-requiring enzyme-1 (IRE1), which mediate three signaling pathways
Ini akibat adanya plak yang terbuat dari campuran kalsium, lemak, kolesterol, dan produk buangan sel tubuh lainnya akibat proses oksidasi lipid
