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Nat Commun 15 , 6152 (2024)

As expected, the transdifferentiation process was inhibited in SC-islets treated with both trans-ISRIB and ZnPTO, as evidenced by a reduced proportion of SC- cells compared with that in SC-islets treated with ZnPTO alone (Fig

In contrast, glutathione (CAS 70-18-8) has a molecular formula of C10H17N3O6S and molecular weight of 307.32 g/mol, presenting as a white crystalline powder

Although GSH is not alone responsible for these protective mechanisms, the hepatic production of GSH seems to be essential to survival, with knockout mice dying within months secondary to inflammation and hepatic steatosis resulting in liver failure [21]