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Verkhratsky et al., 2018
When I asked about the decision, she crossed her arms and furrowed her brow
It is important to note that the majority of this mechanistic research has been conducted in cell culture and animal models, with a significant proportion originating from a single research group
The clinical signal began with a phase 1b study showing that concomitant cagrilintide plus semaglutide 2.4 mg was well tolerated in healthy volunteers, [6] and a phase 2 trial in people with type 2 diabetes and overweight, where CagriSema produced numerically greater weight loss (~15.6%) than semaglutide (~5.1%) or cagrilintide (~8.1%) alone
