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The mechanism involves clearance of senescent Leydig cells that secrete pro-inflammatory SASP factors (IL-1, IL-6, TGF-) which impair testosterone production in neighboring healthy cells
First, the distal heme His64 (HisE7) must unbind from the heme iron to allow ligand binding (FIGURE 1)
Prof Ugur Sahin, CEO and co-founder of BioNTech, said new data indicated that "vaccine-induced protection against infection and mild to moderate disease wanes more rapidly than was observed with prior strains"
