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A 2012 systematic review and meta-analysis, along with a 2013 controlled clinical trial, showed that ALA is an effective drug in the treatment of diabetic neuropathy, which affects about 50 percent of people with diabetes

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Hauser, Robert A.|Ellenbogen, Aaron L.|Metman, Leo Verhagen|Hsu, Ann|O'Connell, Martin J.|Modi, Nishit B.|Yao, Hsuan-Ming|Kell, Sherron H.|Gupta, Suneel K
others are harbingers of systemic or genetic disease, and some can be associated with life-threatening medical conditions that require immediate intervention