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In addition, each of the end organs is tied to other organ systems hormonally via a series of networks or axes

In the overall analysis of IC 50 sensitivity versus differentiation state, we combined p values by first adapting Browns method, a more conservative extension of Fishers method, to account for reduced independence of testing the same cell lines using different inhibitors (Poole et al., 2016)

Its a two-way street in IBD, with the gut microbiome changes potentially causing high homocysteine, but then high homocysteine will increase the inflammation in the gut.[ref] Gastrointestinal production of homocysteine: Gut microbes that produce folate: The amount of folate produced by the gut microbiome is on a similar scale to what we get from food, so it is a significant source of folate for most people