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This exposure also disrupted various cell-specific responses, including energy metabolism, mitochondrial function, and proteostasis, particularly in excitatory neurons, manifesting as reduced motor function and neuronal loss, PS-NPs exposure decreased ATP content and reduced the expression of ATP-related genes and proteins in the substantia nigra and striatum of mice, demonstrating a close relationship between energy metabolism disorders and neurodegeneration (32), Polystyrene nanoplastics (PS-NPs) can induce Parkinson's disease-like neurodegeneration in mice through energy metabolism dysfunction

FOXO4-DRI PH-FOXO4-001 Specifications Purity (HPLC) 99% Size 10mg Molecular Weight 3400 Da Catalog No

[DOI] [PubMed] [Google Scholar] Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression