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when the intracellular Fe2+ overload exceeds the caching capacity of ferritin, and intracellular free iron generates ROS through the fenton reaction, and glutathione (GSH), one of the critically important antioxidants in cells, is catalyzed by peroxidase to oxidized glutathione (GSSG) during lipid peroxidation, and inhibit lipid peroxidation-induced ferroptosis (119)

PGE2 also facilitates Th17-mediated inflammation and fibrosis via IL-17, amplifying liver injury 135,136,137

doi: 10.3390/antiox8090392, 53

B12 is essential for the methylation reactions required to produce the lipids and proteins that constitute myelin
