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Another relatively novel role of NAD + is involvement in forming non-canonical caps on the 5 end of RNA that mark RNA for degradation in eukaryotes 337339

A randomised controlled trial published in Clinical Infectious Diseases demonstrated that Thymosin Alpha-1 treatment in severe COVID-19 patients reduced 28-day mortality by 30% compared to standard care alone.17 While this was acute disease, not long COVID, it confirms the biological plausibility of the immune mechanism

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