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NAM, a metabolite in the salvage pathway, is reduced in both CSF and serum from ALS patients compared with healthy people
Data availability The authors declare that the data supporting the findings of this study are available within the Article, Source Data, and its Supplementary Information
The intracellular pool of folates also is involved in the regulation of homocysteine metabolism by supplying 5-methylTHF
When drugs have active metabolites, it is necessary to know not just the half-life of the parent drug but the half-life of the active metabolites, as well
