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Saharan VA, Kulhari H, Jadhav HR

Moreover, the LOPs cyclopentenone isoprostanes behave as negative feedback regulators of the inflammatory response in LPS-activated macrophages by inhibiting the degradation of IkB and subsequent nuclear translocation and transcriptional activity of NF-kB, as well as the expression of inducible NOS and COX-1 inhibiting the pro-inflammatory status (Musiek et al., 2005)

The Steap proteins are metalloreductases
