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A Liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches
In states of IR, there is a reduction in the expression of IRS-2, which results in an increase in the expression of SREBP-1c and a corresponding elevation in the rate of DNL (Stefan et al., 2008)
But exercise provides cardiovascular conditioning, bone loading, neuroplasticity, and psychological benefits that MOTS-c cannot replicate
