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Transgenic mice lacking LEC-specific MHC-II expression displayed attenuated heterotopic tumor growth, accompanied by elevated numbers of tumor-specific CD8 + and effector CD4 + T cells, as well as reduced numbers of T regulatory CD4 + cells in the TME (104)

Liver cirrhosis represents a post-injury liver repair response wherein hepatic stellate cell (HSC) activation plays a pivotal role, alongside liver sinusoidal endothelial cells (LSECs) regulation, cytokine release, and fibrous scar tissue deposition (Kisseleva and Brenner, 2021)

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Precise mapping is vital for planning surgical interventions like myomectomy