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Peptide drugs with one disulfide are often limited to a formulation space at acidic pH, because formulation under neutral and basic conditions can promote oligomer formation through disulfide shuffling

(166) studied the impacts of RES activity in both in vitro and in vivo models of PD, as well as the molecular mechanisms behind it

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The importance and diversity of liver functions in young children should be noted: it is not only bile production, general metabolism, detoxification, but also, importantly for pediatric liver recipients, the liver works as an immune organ, maintaining overall immune homeostasis of the body (Figure 2)