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Protocol Initiation: Treatment begins with conservative dosing that is gradually optimized based on symptom response and lab results

Additionally, key binding residues such as His251 and Tyr235 align with known functional sites critical for TPH activity, as demonstrated in structural studies of the enzyme [89]

For topical use, applying it once daily instead of twice and keeping the skin well moisturized can help calm irritation

The alkaloids contents in this study were analysed using mass spectrometry (Table S2) and their chromatographic profiles were further confirmed by other studies (Figure S2-S8) [58,59,60,61,62]