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Furthermore, curcumin activates the nuclear translocation of NRF2, which leads to enhanced phagosomelysosome fusion ( Figure 3 )

Abstract Neuropathic pain, a disease of the somatosensory nervous system, afflicts many individuals and adequate management with current pharmacotherapies remains elusive

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Interestingly, enhanced protein stability at low pH as a strategy to avoid acid induced unfolding has also been observed in many proteins including cytokines, interleukin-2 (IL-2) and granulocyte colony stimulating factor (G-CSF), which usually get internalised in acidic endosomal compartments, and capsid proteins which ensure viruss survival in acidic intestinal tract 18,19,20