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where S is the substrate (GSH), v is the reaction rate, k1 is the apparent first-order rate constant k1 was calculated based on the slope of fitted v -[ S ] curve

As of 2024, there are small studies to suggest that topical or oral formulations of glutathione can help reduce melasma severity

Figure 3B shows network estimates of treatment effect on Hb levels for different administration routes compared to the oral route

(3) Interested Parties and Technical Expert Panel (TEP) Input In our development and specification of this measure, we employed a transparent process in which we sought input from interested parties and national experts and engaged in a process that allowed for pre-rulemaking input, in accordance with section 1890A of the Act