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In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye in an ear meets a long standing need for suitable testing methods that are applicable to the development of intratympanic otic formulations or compositions suitable for human use

The respective macrocycles were characterized in vitro by surface plasmon resonance (SPR) and all exhibited strong affinity to the Met ectodomain ( K D =219 nM

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