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Thus increased oxidative stress, loss of Na + /K + -ATPase activity, and altered biochemical markers of mitochondrial function play a role in the increased excitotoxicity in individuals with hyperprolinemia
Similar studies using inactivated whole-virus or viral-vector-based vaccines for SARS-CoV or MERS-CoV resulted in immunopathology following viral challenge 59,60,61 , which were linked to Th2-cytokine-biased responses 55 and/or excessive lung eosinophilic infiltration 57
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