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Beneficial role of vitexin in Parkinsons disease

Interestingly, pre-treatment of plants with H 2 O 2 makes them more tolerant to biotic/abiotic stresses (Hossain et al., 2 O 2 was also noted for its regulatory functions in photosynthesis, cell cycle, development, senescence, and apoptosis (Mittler et al., 2 O 2 has been accepted as a central component of signal transduction pathways in plant-adaptation to altered environmental conditions as it is both the only ROS with high permeability across membranes (that enables the transport of signals to distant sites) and its high stability when compared to other ROS with ~1 ms half-life (Bienert et al., 2 O 2 is disturbed, its overproduction results in significant damage to cell structures (Anjum et al., 2015)

Whilst systemic corticosteroids and conventional immunomodulators have been the primary therapeutic agents, evolving strategies, including biologics and small molecules targeting tumour necrosis factor, different cytokines, or Janus kinase signalling pathways, signify a shift towards a precision management paradigm that considers individual clinical presentations

2014 Nov 19;19(11):19066-77.