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Human Microbiome of the Upper Gastrointestinal (GI) Tract Although the microbiome of the human lower gastrointestinal tract has been most extensively studied there are relevant bacteria in the upper gastrointestinal tract that includes the oral cavity and the esophagus

But that purity only matters if proper storage is maintained from delivery through administration

Effects of short-term modified fasting on sleep patterns and daytime vigilance in non-obese subjects: results of a pilot study

Microbes can play a direct role in the activation and inactivation of drugs via biotransformation of drug molecules into secondary metabolites (Panebianco et al., 2018)
