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The extracellular degradation of GSH occurs on the surface of the cells that express the enzyme -glutamyl transpeptidase and the dipeptidases found in the external plasma membrane (Figure 5)

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Abbreviations HGF hepatocyte growth factor ICIs immune checkpoint inhibitors TME tumor microenvironment EMT epithelial-mesenchymal transition HNSCC head and neck squamous cell carcinoma RTKs receptor tyrosine kinases METex14 MET exon 14 skipping mutations NSCLC non-small cell lung cancer CAFs cancer-associated fibroblasts TAMs tumor-associated macrophages MDSCs myeloid-derived suppressor cells NK natural killer DCs dendritic cells ECM extracellular matrix Chi3L1 chitinase-3-like-1 Treg T regulatory CRC colorectal cancer GC gastric cancer IL-6R interleukin-6 receptor MMPs matrix metalloproteinases HIF1 hypoxia-inducible factor 1 IFN- interferon-gamma HCC hepatocellular carcinoma CTLs cytotoxic T lymphocytes MSCs Mesenchymal stromal cells CTLA-4 cytotoxic T-lymphocyte-associated protein 4 APCs antigen-presenting cells ORR objective response rate PFS progression-free survival OS overall survival GSK3 glycogen synthase kinase 3 Authors contributions YX, CYH, and MZ wrote the original draft and reviewed, edited, and prepared the figures and tables