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INTRODUCTION Harvey Cushing proposed in 1912 in his monograph The Pituitary Gland the existence of a hormone of growth and was thereby among the first to indicate that the primary action of growth hormone (GH) was to control and promote skeletal growth
However, the aforementioned enzymes along with a regulatory protein named PcaR are encoded by a cluster of genes located on the pA plasmid
Besides, EpCAM overexpression is related to Wnt/-catenin pathway activation in cancers, which is a potential causal pathway for cytoplasmic and nuclear accumulation of -catenin, indicating proliferation and reduced apoptosis in cancer cells [141]
