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178,179 Multiple systematic reviews of clinical trials and case reports have found that low-dose naltrexone probably reduces pain and improves quality of life in people with fibromyalgia, but can also cause adverse side effects such as insomnia, vivid dreams, and digestive upset

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Molecular Cancer , 21 ( 1 ), 30

Under the enzymatic regulation of ACSL4 and lysophosphatidylcholine acyltransferase 3 (LPCAT3), PUFAs are converted into phospholipid-PUFAs (PL-PUFAs), which are subsequently oxidized by ALOXs into phospholipid hydroperoxides (PL-PUFA-OOH), triggering ferroptotic cell death [34]