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Description

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The currently approved recombinant humanized monoclonal biologics for patients with demonstrated eosinophilia include: Omalizumab (FDA approved in 2003) anti-IgE Mepolizumab (FDA approved in 2015) IgG1k anti-IL5 Reslizumab (FDA approved 2016) IgG4k anti-IL5 Benralizumab (FDA approved 2017) afucosylated IgG1k against the IL-5 receptor -subunit (IL-5R) Dupilumab (FDA approved 2017) anti-IL-4R (IL-4 receptor -subunit) inhibits both IL-4 and IL-13 that bind to the same IL-4 receptor Omalizumab was the first FDA approved biologic therapy for asthma, and remains the most widely studied agent in this relatively new treatment category

First, the identified candidate genes and pathways were derived from transcriptomic and integrative bioinformatics analyses, and causal relationships with chemoresistance were not experimentally validated