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Discussion While we and others have shown that HTC can be used to reshape the neosubstrate scopes of E3 ligase ligands 13,30,71,72,73,74,75,76,77,78,79 , a generalizable solution for the target-centric discovery of molecular glues has remained elusive

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In addition to its role in cellular metabolism, arginine methylation also regulates the development of CD8 + T cells and other cell types