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Duzel et al., Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights, World J
The p K a of the histidine imidazole group is 6.5, and thus histidine behaves as hydrophobic residue at neutral pH, whereas it is protonated and behaves as a basic peptide in the slightly acidic endosomal milieu
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