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TLR3 detects double-stranded RNA (dsRNA) [21], TLR7 and TLR8 recognise single-stranded RNA (ssRNA) [22], and TLR9 is activated by DNA containing unmethylated CpGs which are abundant in microbial but rare in vertebrate genomes (i.e., 6090% of mammalian CpGs are methylated) [23,24]

Venugopal S, MD, Issa GC, MD, Konopleva M, MD, PhD, DiNardo CD, MD, MSCE, Borthakur G, MD, Jabbour EJ, MD, Pemmaraju N, MD, Yilmaz M, MD, Short NJ, MD, Maiti A, MBBS, Sasaki K, MD, PhD, Masarova L, MD, Pierce SA, BSN, BA, Takahashi K, MD, PhD, Tang G, MD, PhD, Loghavi S, MD, Andreeff M , MD, PhD, Bhalla KN, MD, Garcia-Manero G, MD, Ravandi F, MBBS, Kantarjian H, MD, Daver N, MD

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(A) 2 hours (h), (B) 6 hours, and (C) 12 hours after the last challenge with OVA, the AR was recorded