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We also found that the Trx system showed a strong correlation with immunity in this part of the analysis, which is consistent with some of the recent studies reported [65-67]

[3] In this system, the H protein is a free lipoyl domain with additional helices, the L protein is a dihydrolipoamide dehydrogenase, the P protein is the decarboxylase, and the T protein transfers the methylamine from lipoate to tetrahydrofolate (THF) yielding methylene-THF and ammonia

Given these multiscale findings, spatiotemporal level changes in brain GSH and other antioxidants may indicate that certain brain regions, in particular, metabolically expensive hub regions (e.g., posterior cingulate cortex) (Badhwar et al., 2017, Tomasi et al., 2013), are more vulnerable to aging-related OS (Badhwar et al., 2017, Hahn et al., 2022, Tomasi et al., 2013)