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Understanding whether vitamin B12 is water-soluble helps explain its absorption mechanisms, storage capacity, and why deficiency develops gradually despite efficient hepatic reserves

However, the most widely cited study supporting this approach only reported results for a total of 34 treated patients at three different sites, included a nonrandomized control group, and lacked a blinded evaluation of outcome

This also suggests that PKA may indirectly activate non-HSL-mediated TAG lipolysis
