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In regard to DPI, we previously demonstrated that low micromolar concentrations effectively reduced tumor growth and metastasis in a MYCN-driven zebrafish model of NB, with low associated toxicity ( A limitation of this study is the discrepancy between the strong in vitro synergy of the MitoQ + DPI combination and its limited effectiveness in in vivo models of NB

The preclinical evidence is robust, consistent, and mechanistically plausible, but the gap between rat sciatic nerve transection models and human diabetic neuropathy is significant

BPC-157 studies demonstrated accelerated healing in Achilles tendon transection models[7], while TB-500 showed enhanced wound healing effects in various injury models[8]