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FGF21 as modulator of metabolism in health and disease

reassessment should occur after 812 weeks with clinical guidance

It appears that the IL-6 secreted into the blood crosses the blood-brain barrier in endothelial cells, activates microglia, and starts a cascade of inflammatory effects that result in activation of inflammasomes, secretion of IL-1 beta, and other downstream neurobiological changes associated with depression

Cell 184 , 3573-3587 e3529