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A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion

doi: 10.1111/fcp.12782 [DOI] [PMC free article] [PubMed] [Google Scholar] 33.Kashyap PA-O, Singh D, Nair A, et al

TMZ is the most commonly used chemotherapeutic drug in the post-surgical treatment of GBM, and it directly damages the tumor cells by methylation of the purine base of tumor cells [30,31]

RK12V-SP cells showed self-renewal capacity, the potential to develop into stromal cells, reduced expression levels of differentiation markers, long-term proliferating capacity in cultures, and enhanced tumorigenicity, indicating that RK12V-SP cells have cancer stem-like cell features