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Additionally, ITCs may enhance antitumor immunity: in experimental models, they promote the activity and proliferation of immune effector cells such as natural killer and T cells, contributing to immunosurveillance against tumors (113)
Brown KL, Hakimi JM (1984) Heteronuclear NMR studies of cobalamins
Conversely, reducing the glycolytic activity in T cells, such as through inactivation of the glycolytic master regulator HIF-1, promotes a shift in CD8 T cells towards greater reliance on mitochondrial respiration, thereby enhancing their stemness during chronic viral infection [18]
