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Description
Metformin causes a modest inhibition of mitochondrial respiratory chain Complex I, leading to a mild reduction in adenosine triphosphate (ATP) synthesis and a concomitant increase in adenosine monophosphate (AMP) cellular levels

thus, reducing AGEs, particularly through natural substances, may help mitigate their effects [8]

doi: 10.1016/S0140-6736(11)61752-2 12 FormanH

A: Theres minimal downtime
