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The synaptic mechanisms of mGlu 2/3 -modation of neurochemical and behavioral responses to drugs of abuse remain unclear, and may not be mediated by heteroreceptor activity on the terminals of dopaminergic neurons (Pehrson and Moghaddam, 2010)

Lifestyle factors, including irregular meal patterns and low fruit consumption, were also linked to PHG, with 54.1% of students with gray hair reporting poor quality of life, particularly males and rural residents

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