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Notably, in a recent umbrella review of 14 meta-analyses, assessing pro/synbiotics on weight changes, most studies revealed a decrease in BMI and/or weight, favoring pro/synbiotics compared with placebo ( Several possible mechanisms have been conceived for the favorable impacts of synbiotics supplementation on anthropometric indices, mediated through the complementary/synergistic effects of their pro- and prebiotic compartments (38)

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Under oxidative stress conditions, healthy mitochondria promptly increase mitophagy level to remove damaged fellows rejuvenating the mitochondrial population and sending fragments of mtDNA as SOS signals to all systems in the human body