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First, the extent to which mitochondrial dysfunction, shifts in heteroplasmy, or accumulation of mutant mtDNA directly disrupt epigenetic reprogramming, and the conditions under which such disruptions are transmitted across generations, are not yet clear

Urgent referral (two-week wait) is required for mouth ulcers persisting for more than three weeks, as per NICE suspected cancer guidelines

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This can show up as symptoms such as delayed growth and development (failure to thrive), regression in neuromotor skills (such as losing the ability to roll over or grasp objects), failure to maintain eye contact (even in an infant who previous could do so), general muscle weakness, lethargy, excessive sleepiness, feeding difficulties, and even brain shrinkage