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The current consensus among many practitioners is that some variants in CBS (especially the CBS 699) causes homocysteine to move down too quickly (not braking enough), stressing SUOX, creating excess glutamate, and stressing the adrenals
[DOI] [Google Scholar] Fenn J

Understanding your glutathione status may help you: Your kit includes everything you need to collect a simple finger-prick blood sample at home and return it to our laboratory for analysis

Ultimately, 178 studies were included, with data extraction emphasizing mechanisms, efficacy, limitations, and future directions
