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Despite these major changes in myelin, OLs, and A immunoreactivity, no cognitive impairment or hippocampal pathology was detected in APP/PS1 mice after cuprizone treatment

altered expression of Cyp2e1 or conjugation enzymes 15,16 ) or environmental exposures (alcohol 17 , drugs 14,18 , or microbiome composition 19 )

10.1007/s00595-007-3706-2 52 ParkJ

The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake