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High homocysteine levels are problematic because they have been linked to heart disease and atherosclerosis

doi: 10.1016/j.actbio.2019.05.018

discovered that smoking lowers macrophage expression in OLL, which may change immune surveillance and malignant transformation pathways (Alrashdan et al., 2016a)

In fact, altered one-carbon metabolism has been associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD)