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Description
In pancreatic cancer, cancer-associated fibroblasts (CAFs) drive resistance to platinum through the nuclear translocation of PKM2, the upregulation of the expression of glycolysis-related genes, and the secretion of IL-8, all of which enhance DNA damage repair [59]
This mechanism is particularly relevant for men with circulatory-related ED, often classified as arteriogenic ED
risk of abnormal male genital development in male fetuses
However, the subcellular localization or lack of metal ions may limit the antioxidant effect of enzymes
