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, Akagi Y., Kawahara A., Kinugasa T., Romeo K., Yoshida T., et al

In idiopathic infertility, subtle disturbances in ROS-mediated signaling may manifest as functional impairments that evade detection by conventional semen analysis (4)

have also demonstrated that CO negatively regulates endothelial cell apoptosis, triggering the activation of p38 mitogen-activated protein kinase (MAPK -p38) (215), while pharmacological induction of HO-1 activity decreases blood pressure in spontaneously hypertensive rats (214)
