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Mol Cell 2016;61:520-34

Importantly, CYP2E1-overexpressing HepG2 cells were previously validated for the study of APAP hepatotoxicity, with formation of APAP-protein adducts, mitochondrial damage, and cell death occurring similar to primary mouse and human hepatocytes [51], and our preliminary doseresponse and time course data were consistent with those earlier results (Suppl

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In addition, combined treatment with GPNA and a monoclonal antibody (cetuximab) targeting EGFR effectively suppressed the growth of gastric cancer cells in vitro and in vivo 86