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By blocking NNMT, 5-Amino-1MQ helps preserve nicotinamide adenine dinucleotide (NAD) , a coenzyme essential for mitochondrial energy production, metabolic flexibility, and fat oxidation

Importantly, animals were singly housed to eliminate the exchange and cross-contamination of intestinal microbiomes, a factor that potentially biases studies with group-housed animals by minimizing microbiome variations for co-housed animals within a cohort

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Neither compound should be considered a licensed medicine in the UK, and both require careful scrutiny before any consideration of use