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The other classes of ALDH are distributed widespread in human body but do not participate in acetaldehyde oxidation

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Lead accumulation in tissues promotes oxidative DNA damage, and causes anemia, in part through inhibition of the activity of -aminolevulinic acid dehydratase, an enzyme involved in the biosynthesis of heme [17, 24]

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This suggests that knockdown of the YTHDC1 gene did not result in the upregulation of both GPX4 and FSP1 mRNA expression in A549 and H1299 cells

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10.1038/ncb3064 62 FuD.WangC.YuL.YuR

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